Research reveals claudins' role in paracellular transport disruptions in kidney diseases, suggesting pathways for treatment.
Claudins form segment-specific paracellular pathways that enable efficient ion and water reabsorption with low metabolic cost along the nephron. Mutations with loss of function of claudins cause tubulopathies with salt loss, hypomagnesemia, and/or nephrocalcinosis and kidney stones. Future studies using inducible and segment-specific models will be essential to identify strategies to restore paracellular transport in kidney disease.
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Sassi et al. (2026) studied this question.
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