Key result
Cortical distal nephron chloride transport, mediated by renal intercalated cells in the connecting segment and cortical collecting duct, plays a crucial role in regulating acid-base balance, vascular volume, and blood pressure.
Design
Review
Authors
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May inform targeted hypertension research; leaves open clinical translation pending interventional studies.
This review provides a comprehensive overview of the mechanisms of chloride transport in the cortical distal nephron and their critical role in volume homeostasis and blood pressure regulation.
Wall et al. (2013) conducted a review in Volume homeostasis and blood pressure regulation. Cortical distal nephron Cl- transport was evaluated. Cortical distal nephron chloride transport, mediated by renal intercalated cells in the connecting segment and cortical collecting duct, plays a crucial role in regulating acid-base balance, vascular volume, and blood pressure.
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