Cost-effectiveness analyses of quadrivalent influenza vaccinations in the general European population – a systematic review

This review suggests that vaccination programs with quadrivalent influenza programs are cost-effective compared with no influenza vaccination, regardless of the modelling assumptions. Their implementation should always be based on multiple factors, such as cost-effectiveness, the latest recommendations on optimal effectiveness for each influenza season, and ethical considerations. These results may have been influenced by the clinical and epidemiological validity of the data used by the included studies and the limited number of included analyses, most of which were industry funded.