Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Giulia Nobile; Laura Tassi; Marta Ponzano; Piergiorgio d'Orio; Alessandro Consales; Luca Bosisio; Stefano Francione; Gabriele Arnulfo; Maria Pia Sormani; Lino Nobili; Roberto Mai

doi:10.1002/epi.70231

April 3, 2026EpilepsiaOpen Access

Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

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Key Points

To investigate how pediatric cortical responsiveness to intracerebral stimulation varies with age and area specificity.
Monitored pediatric patients during stereoelectroencephalographic procedures.
Examined effects of age on cortical responsiveness to intracerebral stimulation.
Assessed multidomain responses across different age groups.
Cortical responsiveness increases with age among pediatric patients.
Older children exhibit more varied multidomain responses.
Responsiveness remains unaffected by medication burden, cognitive level, or stimulation frequency.

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Implication

Observational study shows greater cortical responsiveness with age in children, suggesting new clinical mapping strategies.

Abstract

Pediatric cortical responsiveness to IES rises with age and is independent of medication burden, cognitive level, and stimulation frequency. Older children also show more multidomain responses, consistent with developing large-scale integration. These results can inform age-aware stimulation mapping in clinical practice.

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Cite This Study

Nobile et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcc0a79560c99a0a2641 https://doi.org/10.1002/epi.70231

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Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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