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The study aims to explore the relationship between KRAS activity and its impact on glycolysis and immune suppression in metastatic pancreatic cancer.

Kras Activity-Linked Glycolysis and Immunosuppression in Metastatic Pancreatic Cancer

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The study aims to explore the relationship between KRAS activity and its impact on glycolysis and immune suppression in metastatic pancreatic cancer.
Evaluated mRNA and protein expression in needle-biopsied liver metastases from pancreatic cancer patients.
Calculated KRAS signature scores based on gene expression data.
Used weighted co-expression network analysis to identify KRAS-related gene modules.
Performed hierarchical clustering to classify KRAS-related subtypes.
High KRAS signature scores were linked to worse overall survival (hazard ratio: 1.895).
90.9% of KRAS mutated samples showed high KRAS signature scores (P=0.004).
DUSP4 mRNA and several glycolytic proteins were up-regulated in high KRAS signature scores.
Down-regulation of immune profile genes, such as CD4 and CD8, was observed in high KRAS activity tumors.

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Comprehensive analysis links KRAS activity to poor survival outcomes in metastatic pancreatic cancer, indicating metabolic and immune implications.

Mitsunaga et al. (2026) studied this question.

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Comprehensive analysis links KRAS activity to poor survival outcomes in metastatic pancreatic cancer, indicating metabolic and immune implications.