What question did this study set out to answer?

This research investigates the efficacy of KAT6i prifetrastat in combination with PI3K pathway inhibitors for treating PIK3CA mutated ER+ breast cancer.

April 5, 2026Cancer Research

KAT6i Prifetrastat Enhances Efficacy with PI3K Inhibitors in PIK3CA Mutated ER+ Breast Cancer

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Authors

KBKamakoti Prakash BhatPfizer (United States)JCJoan CaoPfizer (United States)CPChristopher Beldon ProffittPfizer (United States)

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Implication

Preclinical evaluation demonstrates superior efficacy of KAT6i with PI3K inhibitors in ER+ breast cancer, suggesting new treatment options.

Key Points

This research investigates the efficacy of KAT6i prifetrastat in combination with PI3K pathway inhibitors for treating PIK3CA mutated ER+ breast cancer.
Evaluated prifetrastat across various breast cancer cell lines.
Conducted in vitro drug combination studies with PI3K inhibitors.
Performed transcriptomic and chromatin accessibility analyses.
Tested drug efficacy in PDX (patient-derived xenograft) models.
Prifetrastat showed strong anti-tumor activity in both PIK3CA mutant and WT ER+ breast cancer cell lines.
Combination treatments exhibited synergy, leading to greater suppression of ER pathway genes.
Triple therapy with prifetrastat, Fulvesterant, and PI3K inhibitors resulted in significant tumor growth inhibition in vivo.

Cite This Study

Bhat et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcfda79560c99a0a2c14 https://doi.org/10.1158/1538-7445.am2026-4499

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Implication

Preclinical evaluation demonstrates superior efficacy of KAT6i with PI3K inhibitors in ER+ breast cancer, suggesting new treatment options.

KAT6i Prifetrastat Enhances Efficacy with PI3K Inhibitors in PIK3CA Mutated ER+ Breast Cancer

Discussion

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Implication

Key Points

Cite This Study

KAT6i Prifetrastat Enhances Efficacy with PI3K Inhibitors in PIK3CA Mutated ER+ Breast Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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