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April 5, 2026Cancer Research

Abstract 5550: T cell transcriptome is altered by Talquetamab in presence of GPRC5D on MM cells

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Authors

UMUmair MunawarALAlexander M. LeipoldSHSeungbin Han

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Overview

Single cell sequencing reveals talquetamab enhances T cell activation in multiple myeloma, indicating new immunotherapy potential.

Key Points

  • This research aims to explore how talquetamab affects T cell function and gene expression in relation to GPRC5D loss in multiple myeloma.
  • Generated GPRC5D knockout models using CRISPR-Cas9 technology.
  • Established cocultures with healthy T cells and talquetamab for 24 hours.
  • Conducted CITE-seq and multiplexed with TotalSeq-C antibodies.
  • Performing sequencing with 10x Genomics and analyzed differential gene expression through Wilcoxon rank-sum test.
  • Observed significant transcriptomic changes in MM cells with GPRC5D loss.
  • T cells activated only in the presence of talquetamab and GPRC5D+ cells, absent in GPRC5DDel/Del models.
  • Identified significant induction of interferon-stimulated genes with talquetamab.
  • Interferon signaling and activation profiles altered in T cell populations in response to GPRC5D status.

Cite This Study

Munawar et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd13a79560c99a0a2efbhttps://doi.org/10.1158/1538-7445.am2026-5550
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