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This research evaluates the efficacy and mechanisms of JAK2 inhibitors in myeloproliferative neoplasms.

In Vitro and In Vivo Screening for JAK2 Inhibitors Discovery

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This research evaluates the efficacy and mechanisms of JAK2 inhibitors in myeloproliferative neoplasms.
Established a murine model of JAK2-driven disease through cell line transplantation.
Monitored disease progression using bioluminescent imaging.
Conducted terminal analyses for splenomegaly, serum biochemistry, and histopathology.
Tested cell lines with varying concentrations of JAK2 inhibitors including Ruxolitinib, Fedratinib, and Tofacitinib.
Quantified inhibition of JAK2-STAT5 signaling and calculated IC50 values.
Mice exhibited splenomegaly, decreased survival, and elevated serum ALT/AST levels.
Ruxolitinib significantly reduced tumor burden and extended survival.
Differential sensitivity to JAK2 inhibitors was observed across cell lines.

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Demonstrates JAK2 inhibitor efficacy in a murine model, suggesting new treatment options.

Li et al. (2026) studied this question.

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