What question did this study set out to answer?

This research aims to uncover the role of KDM2A in the progression from Barrett's esophagus to esophageal adenocarcinoma and evaluate the therapeutic potential of targeting KDM2A.

April 5, 2026Cancer Research

KDM2A-Driven Epigenetic Reprogramming Promotes Barrett’s Esophagus Progression to Adenocarcinoma

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Authors

SDShilpa S. DharThe University of Texas MD Anderson Cancer Center JAJohnson AmoahThe University of Texas MD Anderson Cancer Center FMFerhad MongalUniversity of Houston

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Implication

Experimental study investigates KDM2A inhibition to suppress Barrett's esophagus progression to cancer, suggesting new therapeutic strategies.

Key Points

This research aims to uncover the role of KDM2A in the progression from Barrett's esophagus to esophageal adenocarcinoma and evaluate the therapeutic potential of targeting KDM2A.
Conducted high-plex spatial transcriptomics on patient tissues from Barrett's esophagus to adenocarcinoma stages.
Utilized immunohistochemistry and CRISPR-based models for KDM2A perturbation.
Performed chromatin profiling including CUT&RUN, ATAC-seq, and RNA-seq to analyze enhancer activation and tumor suppressor repression.
Identified 13 transcriptional clusters related to BE and EAC progression, marked by loss of differentiation.
Elevated KDM2A expression correlated with upregulation of PSCA and SPINK1, both linked to malignancy and therapy resistance.
KDM2A inhibition in organoid models reduced oncogenic signaling and restored differentiation.

Cite This Study

Dhar et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd3da79560c99a0a31cb https://doi.org/10.1158/1538-7445.am2026-1361

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Implication

Experimental study investigates KDM2A inhibition to suppress Barrett's esophagus progression to cancer, suggesting new therapeutic strategies.

KDM2A-Driven Epigenetic Reprogramming Promotes Barrett’s Esophagus Progression to Adenocarcinoma

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Implication

Key Points

Cite This Study

KDM2A-Driven Epigenetic Reprogramming Promotes Barrett’s Esophagus Progression to Adenocarcinoma

Discussion

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Implication

Key Points

Cite This Study

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