What question did this study set out to answer?

To investigate the impact of transmissible ER stress from PDAC cells on the immune profile of bone marrow-derived macrophages (BMDMs).

April 5, 2026Cancer Research

Transmissible ER Stress Drives Immune Remodeling in Pancreatic Ductal Adenocarcinoma

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Authors

NRNaveen Chintala RamuluLouisiana State University SPSujata PokharelLouisiana State University NPNishanthini PirashannaLouisiana State University

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Implication

This abstract demonstrates the impact of transmissible ER stress in altering immune responses in PDAC, suggesting critical immune interactions within the tumor environment.

Key Points

To investigate the impact of transmissible ER stress from PDAC cells on the immune profile of bone marrow-derived macrophages (BMDMs).
Utilized murine Panc02 and KPC cells as transmitter cells treated with thapsigargin (Tg).
Cultured murine BMDMs in ER stress-conditioned medium from treated tumor cells.
Analyzed transcriptional changes in BMDMs, focusing on proinflammatory and immunosuppressive markers.
BMDMs showed significant upregulation of proinflammatory modulators like iNOS and NF-κB.
Expression of Arg1 indicated an immunosuppressive macrophage phenotype.
The findings reflect a hybrid state of inflammation and immune regulation in the PDAC tumor microenvironment.

Cite This Study

Ramulu et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd4ea79560c99a0a3406 https://doi.org/10.1158/1538-7445.am2026-7794

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Implication

This abstract demonstrates the impact of transmissible ER stress in altering immune responses in PDAC, suggesting critical immune interactions within the tumor environment.

Transmissible ER Stress Drives Immune Remodeling in Pancreatic Ductal Adenocarcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Transmissible ER Stress Drives Immune Remodeling in Pancreatic Ductal Adenocarcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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