What question did this study set out to answer?

The study aims to develop a mouse model that expresses human IgG1 to assess tolerance against humanized antibody therapies accurately.

Human IgG1-Expressing Mouse Models for Tolerance Induction and Assessment of Therapeutic Antibodies

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This investigation shows improved tolerance to IgG1-based therapies in humanized mouse models, suggesting enhanced clinical relevance.

The study aims to develop a mouse model that expresses human IgG1 to assess tolerance against humanized antibody therapies accurately.
Generated a mouse model expressing human IgG1 and human serum albumin (hSA).
Administered Teropavimab (a human IgG1) weekly for 7 weeks to evaluate tolerance.
Measured circulating Teropavimab levels and ADA formation after repeated dosing.
Mice with hIgG1 expression show increased tolerance to Teropavimab compared to wild-type (WT) and genO-hSA/hFcRn mice.
Teropavimab was detected in all hIgG1-expressing mice after treatment, highlighting better retention.
Only 40% of WT mice retained detectable levels of Teropavimab one week post-treatment.

Pappalardo et al. (2026) studied this question.

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