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This study investigates the photoprotective effects of 3-hydroxy-5,6-epoxy-β-ionone (HEBI) against UVB-induced skin damage.

Photoprotective effect of 3-hydroxy-5,6-epoxy-β-ionone isolated from Sargassum horneri

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This study investigates the photoprotective effects of 3-hydroxy-5,6-epoxy-β-ionone (HEBI) against UVB-induced skin damage.
Isolated HEBI from Sargassum horneri
Evaluated effects in human keratinocytes and fibroblasts
Used zebrafish model for in vivo assessment
Measured cell viability, oxidative stress, and apoptosis
HEBI enhanced cell viability in UVB-exposed keratinocytes
Scavenged reactive oxygen species and reduced apoptosis
Mitigated oxidative stress and increased collagen production in HDF cells
Inhibited lipid peroxidation and cell death in zebrafish

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Exploratory study evaluates photoprotection against UVB in human cells and zebrafish, indicating potential cosmetic uses.

Yang et al. (2026) studied this question.

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