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April 5, 2026Cancer Research

Abstract 1521: Concurrent targeting of tumors and their microenvironment using CAR-T cells specific for fibroblast activation protein alpha

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Authors

LSLarina Tzu‐Wei ShenAIAfsana IslamDFDaiki Fujita

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Overview

Demonstrates improved anti-tumor efficacy of CAR-T cells targeting FAPα in glioblastoma, suggesting a novel approach for solid tumors.

Key Points

  • The aim was to develop CAR-T cells targeting FAPα to overcome challenges of the tumor microenvironment in solid tumors.
  • Generated FAPα CAR-T cells with optimized binding affinity using a high-throughput scFv library.
  • Identified 3 new CAR clones—FL1, FL8, and FL12—with different structural properties.
  • Conducted in vitro and in vivo assessments of cytotoxicity and tumor suppression using glioblastoma cell lines.
  • FL12 CAR-T cells showed enhanced cytotoxicity against FAPα-positive glioblastoma cells compared to parental clones.
  • FL12 demonstrated better preservation of FAPα on target cells and reduced T cell exhaustion.
  • In vivo, FL12 CAR-T cells significantly suppressed tumor growth in a xenograft model compared to conventional CAR-T cells.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd73a79560c99a0a386chttps://doi.org/10.1158/1538-7445.am2026-1521
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