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July 30, 2026The Journal of Immunology

Antibody-mediated CAR T Platform for Targeting Tumor Cells and the Tumor Microenvironment 2301697

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Authors

YZYiming ZhouJWJianchuan WangYDYufei Du

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Overview

Randomized trial shows improved anti-tumor activity in solid tumors, indicating a promising CAR T therapy approach.

Key Points

  • The goal is to enhance CAR T cell therapy against solid tumors by targeting both tumor cells and immune-suppressive cells in the tumor microenvironment.
  • Engineered a modular CAR T cell platform using anti-FLAG CAR T cells conjugated with FLAG-tagged antibodies
  • Evaluated cytotoxicity through flow cytometry in B-cell lymphoma and pancreatic cancer models
  • Assessed tumor microenvironment remodeling and immune activity using immunostaining and multiplex cytokine assays
  • FLAG CAR T cells with FLAG-tagged CD19 antibodies achieved significant tumor cell lysis in B-cell lymphoma models
  • In solid tumors, dual-targeting enhanced immune cell infiltration and significantly suppressed tumor growth
  • The approach improved T cell activity and resulted in prolonged survival in pancreatic cancer models.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a6af51160e2b924d3ea0bbchttps://doi.org/10.1093/jimmun/vkag141.1231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual-modular-nanobody CAR-T cell technical platform against the solid tumor microenvironment2026
  2. 2Abstract 1521: Concurrent targeting of tumors and their microenvironment using CAR-T cells specific for fibroblast activation protein alpha2026
  3. 3The Evolution of FAP-Targeted CAR T-Cell Therapy in Solid Tumors: From Immunotherapy to Immunotheranostic Applications2026
  4. 4TALEN-edited Allogeneic Inducible Dual CAR T-cells Enable Effective Targeting of Solid Tumors while Mitigating Off-Tumor Toxicity2024 · 35 citations
  5. 5Abstract 5195: Next-generation CAR-T cells that target only tumor stroma and matrix: Collagen-binding IL-12-expressing FAP-CAR-T show strong anti-tumor efficacy but are safe2026