What question did this study set out to answer?

This research seeks to enhance the effectiveness of CAR-T cells against solid tumors by developing resistance to inhibitory signals in the tumor microenvironment.

November 1, 2025The Journal of ImmunologyOpen Access

Engineering ‘off-the-shelf’ CAR-T cells resistant to biochemical and immunological barriers in the solid tumor microenvironment 2279

View Full Paper

Ask AI

Bookmark

Authors

SHStephen Matthew Hatfield

Discussion

Member takes

Implication

Engineered CAR-T cells show anti-tumor efficacy in humanized mouse models, highlighting resistance to immunological barriers.

Key Points

This research seeks to enhance the effectiveness of CAR-T cells against solid tumors by developing resistance to inhibitory signals in the tumor microenvironment.
Developed allogeneic CAR-T cells with six targeted gene edits.
Utilized an adenine base editor and CRISPR-Cas12b nuclease for engineering.
Evaluated CAR-T efficacy in humanized mouse models with solid tumor characteristics.
Engineered CAR-T cells exhibited enhanced anti-tumor activity against solid tumors.
Showed improved tumor elimination compared to conventional CAR-T approaches.
Demonstrated resistance to immunological barriers like PD-L1 and TGF-β.

Cite This Study

Stephen Matthew Hatfield (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc359800 https://doi.org/10.1093/jimmun/vkaf283.214

View Full Paper

Ask AI

Bookmark

Engineering ‘off-the-shelf’ CAR-T cells resistant to biochemical and immunological barriers in the solid tumor microenvironment 2279

Discussion

Member takes

Implication

Key Points

Cite This Study

Engineering ‘off-the-shelf’ CAR-T cells resistant to biochemical and immunological barriers in the solid tumor microenvironment 2279

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider