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The aim is to understand the sources of CCL20 and the role of CCR6+ immune-myeloid compartments in gastric cancer.

CCL20-High Chemokine Program Defines CCR6+ Immune-Myeloid Niche in Gastric Cancer

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The aim is to understand the sources of CCL20 and the role of CCR6+ immune-myeloid compartments in gastric cancer.
Chemokine profiling of murine gastric cancer cell lines
Multiplex immunohistochemistry of gastric tumors from preclinical models
Analysis of human gastric single-cell RNA-seq data
Gastric cancer organoids showed a distinct chemokine signature with high CCL20 levels.
High CCR6 expression correlates with reduced overall survival in patients.
Substantial infiltration of CCR6+ immune cells was observed in gastric tumors, linked to tumor burden.

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Research uncovers a CCL20-high immune-myeloid niche in gastric cancer, suggesting new therapeutic strategies.

Ozuner et al. (2026) studied this question.

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