The epitope tax: Antibody feedback and the economics of germinal center competition

Key Points

• This research aims to explore how antibody feedback affects germinal center selection specifically based on epitopes.
• Analyzed the role of antibody feedback in germinal center dynamics.
• Investigated epitope-specific selection processes in germinal centers.
• Examined the effects on immunodominance and antibody diversity.
• Antibody feedback notably shapes germinal center competition.
• Selection in germinal centers is influenced by the specificity of epitopes.
• Changes in immunodominance were linked to variations in antibody breadth.