What does this research mean for the field?

The use of the HA380 hemoperfusion device during cardiopulmonary bypass-assisted cardiac surgery effectively clears inflammatory mediators, reduces early postoperative systemic inflammation, and improves early hemodynamic stability and short-term liver and kidney function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to assess the effectiveness of HA380 hemoperfusion in mitigating the inflammatory response during cardiac surgery using cardiopulmonary bypass.

April 5, 2026Journal of Cardiothoracic SurgeryOpen Access

The combined use of HA380 hemoperfusion in cardiopulmonary bypass alleviates postoperative inflammatory response and organ dysfunction following cardiac surgery

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This research aims to assess the effectiveness of HA380 hemoperfusion in mitigating the inflammatory response during cardiac surgery using cardiopulmonary bypass.
Enrolled 65 patients undergoing elective cardiac surgery with cardiopulmonary bypass.
Divided patients into two groups: experimental (HP group) using HA380 and control without it.
Measured serum levels of various inflammatory markers and clinical indicators preoperatively and postoperatively.
Compared outcomes between the HP and control groups.
Significantly lower levels of IL-1β, IL-6, IL-8, and IL-10 in the HP group post-surgery compared to control.
HP group showed lower vasoactive-inotropic score on postoperative day 1.
Reduction in white blood cells, neutrophils, ALT, urea, and creatinine in the HP group.
No significant difference in ICU stay duration or mechanical ventilation time between groups.

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Implication

Trial evaluates HA380 hemoperfusion efficacy in reducing postoperative inflammation and improving outcomes in cardiac surgery.

Cite This Study

LI et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd9ca79560c99a0a3b15 https://doi.org/10.1186/s13019-026-03955-8

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The combined use of HA380 hemoperfusion in cardiopulmonary bypass alleviates postoperative inflammatory response and organ dysfunction following cardiac surgery

Key Points

Discussion

Implication

Cite This Study

The combined use of HA380 hemoperfusion in cardiopulmonary bypass alleviates postoperative inflammatory response and organ dysfunction following cardiac surgery

Key Points

Discussion

Implication

Cite This Study

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