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April 5, 2026Cancer Research

Abstract 1419: Integrated spatial and genetic lineage tracing uncovers cell state plasticity underlying recurrence in group3 and group4 medulloblastoma.

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Authors

BYBohyeon YuEREmanuele Filiberto RosattiJJJangham Jung

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Overview

Uncovers cell state plasticity in recurrent Group 3/4 medulloblastomas, suggesting mechanisms for treatment resistance.

Key Points

  • To explore the plasticity of cell states in Group 3 and 4 medulloblastomas and their response to therapy.
  • Constructed a single-cell multiomics atlas of G3/4 MBs using 84 tumor specimens from 38 patients.
  • Generated single-nucleus transcriptomic and chromatin accessibility profiles from frozen samples.
  • Utilized spatial transcriptomics with Visium and Xenium on FFPE samples.
  • Incorporated single-cell lineage-tracing data from intracranial xenografts of G3 MB cell lines.
  • Conducted phylogenetic analysis to assess cell state transitions in matched primary and recurrent tumors.
  • Genetic lineage tracing showed stable cell-type fractions in xenografts compared to primary tumors.
  • Matched primary and recurrent tumors exhibited similar developmental compositions.
  • Recurrent tumors demonstrated increased plasticity, transitioning from unipolar brush cell-like to RL progenitor-like states.
  • Regions of high plasticity correlated with disorganized tumor structure.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd9ca79560c99a0a3c1ehttps://doi.org/10.1158/1538-7445.am2026-1419
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 3877: Multi-modal analysis of paracrine signaling in group 3/4 medulloblastoma2024
  2. 2ID #732 Aberrant Developmental Cell-State Programs Drives Heterogeneity in Group 3/4 Medulloblastoma2026
  3. 3Abstract 3502: Loss of histone 3 lysine 9 trimethylation drives recurrence in high-risk pediatric medulloblastoma2026
  4. 4Abstract 2848: MYC and TGFβ promote group 3 medulloblastoma tumor resistance through deregulation of Polycomb targets2024
  5. 5Abstract B063: Unveiling the immune landscape of recurrent, MYC-driven medulloblastoma2024