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April 5, 2026Cancer Research

Abstract 4744: Metabolomic profiling of fresh and formalin-fixed paraffin-embedded samples reveals metabolome alterations in penile cancer

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Authors

AHAndres Enrique Hernandez-GonzalezMSMaría M. Sánchez-VázquezLTLuis Torres-Peña

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Overview

Characterizes metabolomic alterations linked to clinical variables in penile cancer, suggesting potential biomarkers.

Key Points

  • The study aims to analyze metabolomic profiles of penile cancer samples and explore their correlation with clinical variables.
  • Characterization of non-targeted metabolomic profiles of fresh and FFPE penile cancer samples.
  • HPV infection status was determined using commercial HPV genotyping kits.
  • Metabolites were analyzed using GCMS/MS-TQ8050 equipment.
  • Statistical analysis conducted with T-tests and Mann-Whitney tests using MetaboAnalyst 6.0.
  • Fresh samples yielded 52 metabolites; FFPE samples yielded 18 metabolites.
  • Significant correlations found between HPV infection status, tumor stage, and various metabolites.
  • Key metabolites include isoleucine, homoserine, cysteine, glycolic acid, methylmalonic acid, malic acid, and heptanoic acid with p-values < 0.05.
  • No significant correlation identified between tumor grade and metabolomic alterations.

Cite This Study

Hernandez-Gonzalez et al. (2026) studied this question.

synapsesocial.com/papers/69d1fdb0a79560c99a0a3ed1https://doi.org/10.1158/1538-7445.am2026-4744
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