What question did this study set out to answer?

To investigate the antitumor and immunomodulatory effects of ARV-6723 compared to immune checkpoint inhibitors (ICIs) in preclinical models of ICI resistance.

April 5, 2026Cancer Research

Preclinical Activity of ARV-6723 Against T-Cell Exhaustion and ICI Resistance

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Authors

AAAnna C. Van AckerArvinas (United States)WCWilliam L. CorwinArvinas (United States)ADAlbert M. DeBerardinisArvinas (United States)

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Implication

Preclinical evaluation shows ARV-6723 improves antitumor activity in ICI-resistant tumor models, suggesting its promise as a treatment option.

Key Points

To investigate the antitumor and immunomodulatory effects of ARV-6723 compared to immune checkpoint inhibitors (ICIs) in preclinical models of ICI resistance.
Used syngeneic mouse tumor models to study ICI resistance.
Administered ARV-6723 and anti-PD-1/anti-CTLA-4 antibodies in different dosing regimens.
Evaluated tumor growth inhibition (TGI) and immunomodulatory effects via flow cytometry and cytokine analysis.
ARV-6723 induced significant TGI of 27% and 57% in LLC1-IFNγ model, compared to negligible effects of ICIs.
In KPCY model, ARV-6723 achieved TGI of 89%, similar to combined ICI treatment and superior to anti-PD-1 alone.
Mice treated with ARV-6723 exhibited increased effector/memory T cells and NK cells, along with favorable cytokine changes.

Cite This Study

Acker et al. (2026) studied this question.

synapsesocial.com/papers/69d1fdbfa79560c99a0a3f4d https://doi.org/10.1158/1538-7445.am2026-4309

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Implication

Preclinical evaluation shows ARV-6723 improves antitumor activity in ICI-resistant tumor models, suggesting its promise as a treatment option.

Preclinical Activity of ARV-6723 Against T-Cell Exhaustion and ICI Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

Preclinical Activity of ARV-6723 Against T-Cell Exhaustion and ICI Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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