What question did this study set out to answer?

To assess the influence of LEPR and PTGS2 genetic variations on the prognosis of breast cancer outcomes.

Gene Polymorphisms in LEPR and PTGS2 for Prognostic Evaluation in Breast Cancer

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Investigative cohort study evaluates genetic impacts on breast cancer outcomes, suggesting tailored prognostic models.

To assess the influence of LEPR and PTGS2 genetic variations on the prognosis of breast cancer outcomes.
Conducted a prospective cohort study with 1038 Brazilian women with nonmetastatic breast cancer over 10 years.
Genotyped blood samples for 14 SNPs from five genes using Real-Time PCR.
Evaluated survival using Kaplan–Meier method and hazard ratios through Cox regression multivariate models.
Assessed linkage disequilibrium and haplotypes using Haploview.
LEPR rs1137101 was linked to improved disease-free survival (DFS) across various patient subgroups.
PTGS2 rs689466 was associated with worse DFS and breast cancer-specific survival (BCSS), particularly in post-menopausal and obese patients.
Combination of LEPR and PTGS2 polymorphisms provided insights into patient prognosis, indicating the relevance of personalized prognostic models.

Souza et al. (2026) studied this question.

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