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April 5, 2026Critical Reviews in Oncology/Hematology0 citationsOpen Access

Evaluating Quality of Life in Thoracic Malignancy Trials

Evaluating Quality of Life in Thoracic Malignancy Trials: A scoping review on ESMO-MCBS Quality of Life Checklist Adherence and Concordance With Progression-Free and Overall Survival

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Authors

DKDaniela KrepperFSF SalomoneASA Servetto

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Overview

Scoping review evaluates quality of life assessment in trials, revealing limited concordance with outcomes.

Key Points

  • To assess how quality of life is measured and reported in thoracic malignancy trials and its relationship with clinical outcomes.
  • Conducted a scoping review of phase III RCTs published from 2019 to 2023.
  • Included trials that assessed quality of life using EORTC instruments.
  • Evaluated adherence to ESMO-MCBS quality of life checklist criteria.
  • Concordance between quality of life and overall survival was reported in less than 25% of trials.
  • About 70% of trials reported a progression-free survival benefit without corresponding quality of life benefit.
  • More than 80% showed differences in global health quality of life and disease-related symptoms.

Cite This Study

Krepper et al. (2026) studied this question.

synapsesocial.com/papers/69d1fdd4a79560c99a0a427bhttps://doi.org/10.1016/j.critrevonc.2026.105315
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