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Systematic review reveals distinct neuroendocrine neoplasm patterns in inflammatory bowel disease, highlighting management strategies.
NENs in IBD show distinct patterns by IBD type, with significant differences in tumor location, grade, and metastatic rates between UC and CD. These hypothesis-generating observations suggest heightened vigilance after approximately 10 years of IBD or around age 44, focusing on rectal lesions in UC and small bowel/appendiceal lesions in CD. Validation in prospective, population-based studies is needed before these findings can inform clinical practice.
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Khamis et al. (2026) studied this question.
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