Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 9, 2025BiomedicinesOpen Access

The Molecular Landscape of Inflammation in Inflammatory Bowel Disease (IBD): Targets for Precision Medicine

View Full Paper
Ask AI
Bookmark
Share

Authors

LLLoris Riccardo LopetusoMMMarco MurgianoEMElisabetta Mantuano

Discussion

Loading...

Member takes

Overview

Review highlights inflammation, cellular senescence, and fibrosis in inflammatory bowel diseases, suggesting biologics promote mucosal healing and reduce colorectal cancer risk.

Key Points

  • To explore the mechanisms of inflammation and cellular senescence in inflammatory bowel diseases and assess emerging therapies.
  • Review of literature on inflammatory bowel diseases, focusing on Crohn’s disease and ulcerative colitis.
  • Analysis of the role of inflammation, cellular senescence, and fibrosis in disease progression.
  • Evaluation of targeted therapies including biologics and small molecules.
  • Inflammation and cellular senescence are critical mechanisms in the pathogenesis of inflammatory bowel diseases.
  • Emerging biologic therapies show promise in promoting mucosal healing and reducing the risk of colorectal cancer.

Cite This Study

Lopetuso et al. (2025) studied this question.

synapsesocial.com/papers/69253a35c0ce034ddc357b06https://doi.org/10.3390/biomedicines13112738
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unraveling the Complex Pathogenesis, Diagnosis, and TherapeuticInterventions of Inflammatory Bowel Disease2026
  2. 2From Cytokines to Biomarkers: Mapping the Immunopathology of Inflammatory Bowel Disease2025 · 16 citations
  3. 3Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances2026
  4. 4Identifying Potential Targets for the Interception of Inflammatory Bowel Disease: Toward Precision Prevention2025 · 4 citations
  5. 5Systemic dysregulation of the gut microenvironment plays a pivotal role in the onset and progression of inflammatory bowel disease2025 · 32 citations