What question did this study set out to answer?

The research investigates the cellular and molecular mechanisms contributing to treatment resistance and relapse in high-risk neuroblastoma.

Multi-Omic Profiling of Cellular Heterogeneity and Microenvironment in Neuroblastoma Treatment...

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Multi-omic profiling reveals cellular mechanisms of treatment resistance in high-risk neuroblastoma, suggesting new therapeutic strategies.

The research investigates the cellular and molecular mechanisms contributing to treatment resistance and relapse in high-risk neuroblastoma.
Conducted multi-omic analyses including single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics on neuroblastoma tumors.
Performed longitudinal sampling and Nanopore sequencing to assess the genomic and epigenomic landscape.
Used a validation cohort of bulk RNA-seq samples to correlate findings with clinical outcomes.
Identified a distinct ADRN_proliferating neuroblast subtype associated with poor prognosis.
Noted a shift from ADRN to MES neuroblast states during induction chemotherapy and the emergence of ADRN-like cells at relapse.
Found that the tumor microenvironment (TME) became immunosuppressive, marked by SPP1+ macrophages, and remained so at relapse.

Seo et al. (2026) studied this question.

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Multi-omic profiling reveals cellular mechanisms of treatment resistance in high-risk neuroblastoma, suggesting new therapeutic strategies.