The aim of this study was to explore the feasibility and efficacy of regenerative endodontic procedures (REPs) for treating avulsion injuries through a comparative retrospective analysis of avulsed immature permanent teeth treated with apexification (APEX) and REPs. Forty-nine teeth from 39 patients met the inclusion criteria and were divided into APEX (n = 25) and REP (n = 24) groups. Clinical and radiographic data were analyzed, with treatment outcomes categorized as "healed," "healing," or "disease." Quantitative radiographic analysis using ImageJ software measured percent changes in root length and thickness. Multivariable logistic regression identified predictors of ``disease'' treatment outcome. The APEX (n = 25) and REP (n = 24) groups demonstrated balanced baseline characteristics (all P > .05). Analysis identified several prognostic factors, with storage medium (P = .031), root development stage (P = .003), and periodontal healing (PH) type (P .05). REPs represent a viable therapeutic alternative to APEX in the management of avulsed immature teeth and associated with a tendency toward earlier apical closure. Furthermore, the type of PH was identified as a critical prognostic factor, serving as a key indicator for predicting adverse treatment outcomes.
Zhou et al. (Fri,) studied this question.