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April 5, 2026Cancer Research

Modeling Blood-Brain Barrier with PDX-Derived Glioblastoma Microenvironment

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Authors

MZMichelle ZimmerAPAmélie PaillereauTSThomas Sommermann

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Overview

Models glioblastoma behavior in human and mouse systems, revealing implications for drug effectiveness across barriers.

Key Points

  • The research aims to create and validate advanced blood-brain barrier models combined with glioblastoma to enhance drug response evaluation.
  • Developed human and mouse biochip systems with brain endothelial cells, astrocytes, and pericytes.
  • Tested barrier formation in static transwell systems and microfluidic platforms.
  • Evaluated treatment responses using cobimetinib and afatinib across different culture systems.
  • 2D cultures and in vivo studies were sensitive to cobimetinib, unlike the microfluidic model.
  • Afatinib reduced glioblastoma growth in both the biochip and in vivo, indicating effective BBB penetration.
  • The biochip models provide a reliable means to examine drug penetration and tumor response dynamics.

Cite This Study

Zimmer et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe18a79560c99a0a4a40https://doi.org/10.1158/1538-7445.am2026-3401
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