Safety and Biodistribution of Topical Laquinimod, an Immunomodulator Targeting Aryl Hydrocarbon Receptor: The LION Study

Key Points

To assess the safety, tolerability, and biodistribution of topical laquinimod eye drops.
Evaluated laquinimod eye drops in a clinical study design.
Monitored safety and tolerability in participants.
Assessed distribution of the drug in ocular tissues.
Laquinimod demonstrated favorable safety and tolerability profiles.
Biodistribution findings suggest effective targeting of ocular tissues.

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Evaluates laquinimod's safety and distribution in eye drops, indicating potential for steroid-sparing treatment.

To evaluate the safety, tolerability, and distribution of laquinimod (LAQ) eye drops as a potential steroid-sparing anti-inflammatory therapy.

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Feky et al. (2026) studied this question.

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