Computational analysis uncovers molecular mechanisms of SET in chromosome segregation, indicating its importance in cancer suppression.
Carcinogenesis is initiated by genetic damage or mutations and involves multiple genes and signaling pathways. Proper chromosome segregation is essential for its suppression. In this study, we applied computational chemical methods to investigate SE Translocation (SET), a protein implicated in chromosome segregation. The analysis indicates that SET localizes to the centromere through electrostatic interactions between Glu206 of SET and lysine residues of Shugoshin 2 (Sgo2), including Lys38.
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AWAJI et al. (2025) studied this question.
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