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April 6, 2026Cancer Treatment and Research CommunicationsOpen Access

Prognostic Impact of N1 Lymph Node Micrometastasis in T1-2a Non-small Cell Lung Cancer

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Authors

HKHiroyasu KogaYokohama City University Medical CenterTWTetsukan WooYokohama City University Medical CenterMMMai Matsumura

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Implication

Retrospective analysis reveals N1 micrometastasis predicts poorer outcomes in early-stage non-small cell lung cancer, suggesting implications for treatment decisions.

Key Points

  • This study aims to evaluate the prognostic impact of N1 lymph node micrometastasis on outcomes in T1-2a non-small cell lung cancer.
  • Retrospective analysis of patients with T1-2a NSCLC who underwent complete tumor resection and lymph node dissection between 2000 and 2015.
  • Identification of N1 micrometastasis using cytokeratin immunohistochemistry and digital slide analysis.
  • Statistical analysis including univariate and multivariate assessments alongside stabilized inverse probability of treatment weighting (IPTW) adjusted methods.
  • Patients with N1 micrometastasis had significantly worse recurrence-free survival (RFS) and overall survival (OS) compared to those without lymph node involvement.
  • 5-year RFS for patients with N1 micrometastasis was 53.3% vs. 85.1% for those without (P<0.001).
  • 5-year OS for patients with N1 micrometastasis was 61.5% vs. 87.0% for those without (P=0.007).
  • N1 micrometastasis was identified as an independent adverse prognostic factor for RFS (HR 2.589, P=0.003) and OS (HR 2.179, P=0.036).

Cite This Study

Koga et al. (2026) studied this question.

synapsesocial.com/papers/69d34dd49c07852e0af97673https://doi.org/10.1016/j.ctarc.2026.101201
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Also Consider

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  1. 1Micrometastases or Isolated Tumor Cells and the Outcome of Breast Cancer2009 · 538 citations
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  4. 4EGFRandhTERTExpression as a Diagnostic Approach for Non-small Cell Lung Cancer in High Risk Groups2010 · 6 citations
  5. 5Detection of lymph node metastasis in lung cancer patients using a one-step nucleic acid amplification assay: a single-centre prospective study2019 · 19 citations