Abstract Background Biocultural landscapes in Indonesia preserve extensive medicinal plant knowledge, yet many species remain insufficiently examined through integrative ethnographic, ecological, and phytochemical approaches. Among the Bugis–Makassar communities of South Sulawesi, Ficus septica (tobo-tobo/awar-awar) is regarded as a “cooling” plant used to treat heat-related disorders and restore assitinajang (cosmic balance). However, limited research has explored how its cultural classifications correspond to phytochemical properties and how its presence relates to ecological dynamics in karst environments. Methods This study combined in-depth ethnographic interviews, participant observation, and ethnobotanical documentation with Gas Chromatography–Mass Spectrometry (GC–MS) profiling of methanolic leaf extracts of F. septica collected in Balleanging Village, Pangkep Regency. Five purposively selected knowledge holders, including traditional healers and elders, provided detailed narratives on plant classification, preparation techniques, and cosmological meanings. Ecological observations documented the species’ distribution patterns and associated plant–animal interactions within limestone habitats. Results Participants consistently classified F. septica as a penawar (“cooling medicine”) that neutralizes panasa’ (heat imbalance) and strengthens sumange’ (vital force). GC–MS profiling identified fifty-four compounds, dominated by phytol, myristic acid vinyl ester, methyl palmitate, methyl stearate, and rotundifuran—molecules with documented anti-inflammatory, antioxidant, and antimicrobial activities. These pharmacological properties align with local thermal classifications, suggesting a meaningful correspondence between indigenous medical concepts and biochemical evidence. Ecological observations and supporting literature indicate that F. septica exhibits traits consistent with pioneer species in karst substrates and participates in frugivore-mediated seed dispersal networks. Conclusion The convergence of cultural interpretation, phytochemical profiling, and ecological observation suggests that F. septica operates within a localized biocultural system in which healing practices, cosmological ethics, and ecological processes are interconnected. While based on a focused qualitative sample and site-specific ecological documentation, this study highlights the value of integrating traditional ecological knowledge with scientific inquiry to inform culturally grounded conservation strategies in karst landscapes.
Ismail et al. (Sat,) studied this question.