Correlation analysis demonstrates microcirculatory impairment in diabetic foot, suggesting CEUS as a noninvasive evaluation tool.
Serum VEGF and CXCL-12 levels increase in diabetes but slightly decrease when DFU develops, indicating microcirculatory decompensation. CEUS-derived perfusion parameters, especially TTP, can sensitively reflect microcirculatory impairment and are positively correlated with angiogenic factor levels. This study suggests that CEUS provides a novel noninvasive tool for evaluating microcirculatory lesions in diabetic foot, with potential clinical translational value.
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Wang et al. (2026) studied this question.
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