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August 7, 2025Renal FailureOpen Access

Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy

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Authors

QTQingshan TianFZFan ZhangZYZhichao Yang

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Overview

Research demonstrates elevated levels of VEGF-C, VEGF-D, and CXCL-12 in diabetic kidney disease, indicating their potential as biomarkers for severity assessment.

Key Points

  • Plasma levels of VEGF-C, VEGF-D, and CXCL-12 significantly increase in all diabetic kidney disease groups.
  • Correlation analysis shows higher plasma VEGF levels relate to increased creatinine and urinary microalbumin levels.
  • The area under the curve for AUC-ROCs indicates VEGF-D is particularly effective for distinguishing stages of diabetic nephropathy.
  • These findings support using VEGF-C, VEGF-D, and CXCL-12 as biomarkers for early diagnosis and monitoring of diabetic kidney disease.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/689dfe9fd61984b91e13c3ddhttps://doi.org/10.1080/0886022x.2025.2536196
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