Why the study?
What are the predictors of circulating CXCL16 levels in patients with diabetic kidney disease?
Population
134 European patients with diabetic kidney disease with estimated glomerular filtration rate categories…
Design
Cross-sectional
Key result
Prior cardiovascular disease, lower eGFR, and lower serum albumin were associated with higher plasma CXCL16 levels (4.33 vs 3.88 ng/ml for prior cardiovascular disease; p=0.013).
Authors
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May inform vascular risk monitoring in diabetic kidney disease; leaves open CXCL16 as therapeutic target.
Cross-Sectional (n=134)
What are the predictors of circulating CXCL16 levels in patients with diabetic kidney disease?
Absolute Event Rate: 4.33% vs 3.88%
p-value: p=0.013
In patients with diabetic kidney disease, lower eGFR and serum albumin independently predict higher plasma CXCL16 levels, which are also elevated in those with prior cardiovascular disease.
Elewa et al. (2016) conducted a cross-sectional in Diabetic kidney disease (n=134). Prior cardiovascular disease, eGFR, and serum albumin vs. No prior cardiovascular disease was evaluated on Plasma CXCL16 levels (p=0.013). Prior cardiovascular disease, lower eGFR, and lower serum albumin were associated with higher plasma CXCL16 levels (4.33 vs 3.88 ng/ml for prior cardiovascular disease; p=0.013).