Why the study?
Does the sequential theoretical addition of ezetimibe and bempedoic acid improve LDL-C goal achievement and reduce modeled MACE?
Does the sequential theoretical addition of ezetimibe and bempedoic acid improve LDL-C goal achievement and reduce modeled MACE?
Simulation modeling suggests that sequentially adding ezetimibe and bempedoic acid to statin therapy can substantially improve LDL-C goal attainment and theoretically reduce cardiovascular risk.
Sequential theoretical addition of ezetimibe and bempedoic acid increased LDL‑C goal achievement and was associated with modeled reductions in MACE. Risk estimates were inferred from LDL‑C lowering in the simulation.
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Raul D. Santos (2026) studied this question.
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