Panchakarma is a cornerstone of Ayurveda, designed for internal purification and the holistic management of health disorders. In the face of a global surge in chronic diseases-such as diabetes, cardiovascular ailments, autoimmune disorders, arthritis, and neurodegenerative conditions-the limitations of symptomatic modern treatments have made room for integrative and preventive approaches. Panchakarma offers a multidimensional approach that goes beyond symptom management to address the root causes of chronic diseases through detoxification, lifestyle correction, and rejuvenation. Panchakarma, through its five-pronged therapeutic regimen (1- Vamana–therapeutic emesis, 2- Virechana–purgation, 3- Basti–medicated enema, 4- Nasya–nasal administration, 5- Raktamokchana–blood lettig), addresses disease at the root level by eliminating accumulated toxins (Ama), correcting doshic imbalances, and rejuvenating bodily tissues. Evidence- based approaches in Ayurveda are gradually gaining traction, and numerous clinical and observational studies have started validating the efficacy of Panchakarma therapies. Studies demonstrate significant clinical outcomes in chronic diseases when Panchakarma is integrated with diet, lifestyle, and herbal medications. This paper evaluates and compiles the current clinical evidence supporting the efficacy of Panchakarma in managing chronic diseases, including metabolic syndrome, osteoarthritis, autoimmune disorders, and neurological conditions.
1Dr. Shubham Gaurav BAMS MD, 2Dr. Salman Khan BAMS MD, 3Dr. Sanjay Yadav BAMS MD, 4Dr. Abhishek Kumar Shukla BAMS MD, 5Prof. Dr. S. D. Pandey BAMS, MD PhD, 6Dr. Darshana BAMS MD PhD (Wed,) studied this question.