Answers are grounded in this paper and cite their sources.
This research demonstrates a novel reaction forming α-pyrones in high yields, indicating new synthetic pathways for biomolecules.
α-Pyrones, which serve as core structures in many natural products and important biomolecules, exhibit promising biological activities. Herein, we report an efficient N-heterocyclic carbene (NHC)-catalyzed formal [3 + 3] cycloaddition/elimination reaction that directly converts readily available α-bromocinnamaldehydes and pyridinium salts into diverse α-pyrones under mild conditions. This method exhibits broad functional group tolerance and delivers a wide range of substituted α-pyrone derivatives in high yields.
No takes yet. Share an insight, caveat, or question.
Bi et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: