Multi-omics analysis reveals the role of the XRCC gene family in diagnosis, prognosis, and immunity in pan-cancer

Members of the XRCC family have been reported to be closely associated with the initiation and progression of certain human cancers. The purpose of this study is to comprehensively analyze the role of the XRCC family in pan-cancer. In this study, we primarily utilized data downloaded from The Cancer Genome Atlas (TCGA). We investigated the prognostic significance of the XRCC family and its association with tumor mutation burden (TMB), microsatellite instability (MSI), drug sensitivity, and immunotherapy in several human cancers. The findings indicated that the expression of the XRCC family was primarily upregulated in most tumors. The XRCC family was associated with the prognosis of cancer patients. Then, XRCC family genes showed a significant association with tumor immune microenvironment and tumor cell stemness. Finally, we also analyzed the potential role of the XRCC family in cancer therapy. This study conducts a comprehensive analysis of the role of the XRCC family in pan-cancer, which contributes to providing a potential direction for cancer diagnosis and treatment.