Systematic review finds methotrexate controls inflammation in scleritis, suggesting further trials are needed.
The study revealed MTX's clinical significance in managing noninfectious scleritis. Significant results were observed in inflammation control and tolerability; however, the lack of randomized comparator studies limits conclusions regarding MTX's superiority over steroids or placebo. Future controlled trials are needed to confirm comparative effectiveness and refine treatment guidelines.
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Chen et al. (2026) studied this question.
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