Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2026Journal of Cutaneous Medicine and Surgery

Comparative Efficacy of Methotrexate Versus Cyclosporine in the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis: A Systematic Review and Meta-Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

MZMahnoor ZafarMSMuhammad ShumasUNUrwah Noor

Discussion

Loading...

Member takes

Overview

Systematic review evaluates methotrexate versus cyclosporine effectiveness in psoriasis, suggesting comparable outcomes.

Key Points

  • This research aims to compare the efficacy and safety of methotrexate and cyclosporine in treating moderate-to-severe chronic plaque psoriasis.
  • Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
  • Searched databases including PubMed, Cochrane, Embase, and Google Scholar
  • Included four RCTs with 247 participants comparing methotrexate and cyclosporine
  • Utilized a random effects model for analysis
  • No significant difference in PASI 75 and PASI 90 scores between methotrexate and cyclosporine
  • Mean difference in reduction at 4, 8, and 12 weeks was not statistically significant
  • Methotrexate associated with fewer adverse events, but higher risk of elevated liver enzymes

Cite This Study

Zafar et al. (2026) studied this question.

synapsesocial.com/papers/69cd7b475652765b073a91c5https://doi.org/10.1177/12034754261431774
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database2025 · 7 citations
  2. 2RoB 2: a revised tool for assessing risk of bias in randomised trials2019 · 33,428 citations
  3. 3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement2009 · 83,682 citations
  4. 4Methotrexate Hepatotoxicity in Rheumatoid Arthritis: An Analysis of the Physicians’ Policy2019 · 5 citations
  5. 5Calcineurin Inhibitor Nephrotoxicity2009 · 1,500 citations