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December 1, 2025Open Access

Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis.

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Authors

CCChayada ChaiyabutrCWChanisada Wongpraprarut

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Overview

Observational analysis shows methotrexate outperforms cyclosporine and acitretin for psoriasis, suggesting better treatment options.

Key Points

  • Methotrexate was found to be more effective than other treatments for psoriasis.
  • Key evidence indicates a significant increase in drug persistence with methotrexate compared to acitretin and cyclosporine.
  • Assessment using observational data revealed the comparative effectiveness of psoriasis treatments in a real-world scenario.
  • This highlights the need for informed treatment decisions in managing psoriasis with these drugs.

Cite This Study

Chaiyabutr et al. (2025) studied this question.

synapsesocial.com/papers/694027632d562116f28fffa2https://doi.org/10.1097/jw9.0000000000000237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Efficacy of Methotrexate Versus Cyclosporine in the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis: A Systematic Review and Meta-Analysis2026
  2. 2Use of cyclosporine and methotrexate in psoriasis2024 · 1 citations
  3. 3Cyclosporine and Methotrexate in Atopic Dermatitis: Bridging Therapies or Real-World Alternatives?2026
  4. 4Efficacy and safety of cyclosporine a combined with acitretin in moderate-to-severe plaque psoriasis: a randomized controlled trial2025
  5. 5Effectiveness of Methotrexate Versus Cyclosporine in the Management of Moderate to Severe Atopic Dermatitis- Meta-Analysis of Randomised Controlled Trials2024