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June 30, 2024Daehan geonseon hakoeji (Online)Open Access

Use of cyclosporine and methotrexate in psoriasis

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Authors

SYSeok‐Kweon YunJPJin ParkKNKyung‐Hwa Nam

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Overview

Clinical review outlines therapeutic profiles and management strategies for cyclosporine and methotrexate in psoriasis, highlighting personalized risk-benefit assessment.

Key Points

  • To review the mechanisms of action, efficacy, pharmacokinetics, dosing regimens, contraindications, and safety profiles of cyclosporine and methotrexate in psoriasis treatment.
  • Narrative literature synthesis of conventional systemic agents used in the clinical management of moderate-to-severe psoriasis.
  • Evaluation of pharmacologic properties, drug-drug interactions, monitoring parameters, and organ-specific toxicity risks associated with cyclosporine and methotrexate.
  • Conventional systemic agents maintain a critical therapeutic role for moderate-to-severe disease alongside newer biologics and small-molecule therapies.
  • Effective long-term clinical control requires individualized agent selection and dosage titration balanced against drug-specific adverse effects and toxicities.

Cite This Study

Yun et al. (2024) studied this question.

synapsesocial.com/papers/6a92f13e14869e32be2c5e2fhttps://doi.org/10.23203/jksp.2024.21.1.11
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Efficacy of Methotrexate Versus Cyclosporine in the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis: A Systematic Review and Meta-Analysis2026
  2. 2Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis.2025
  3. 3Combination therapy of biologic and non-biologic systemic agents in psoriasis: A narrative review of real-world evidence and clinical positioning2026
  4. 4AN INTENSIVE REVIEW ON THE MANAGEMENT OF PSORIASIS: FUMARIC ACID ESTERS ANALOGS2024
  5. 5Comparison of various psoriasis treatment methods2026