The subject of the research is the quality of life of adolescents and young adults with lymphomas at the stages before and after hematopoietic stem cell transplantation. The object of study is the dynamics of physical, psychological, and social functioning of patients during the peritransplantation period. The article examines in detail aspects of the topic such as: the baseline quality of life before transplantation, the nature of changes in the early post-transplantation period associated with isolation and severe side effects of treatment, as well as the features of the recovery of various spheres of functioning one year after transplantation. Special attention is given to the age-specific characteristics of patients aged 15–25, who are at the stage of emerging adulthood. The work also analyzes the factors that contribute to successful psychosocial adaptation and substantiates the need for specialized psychological support at all stages of treatment. The material for the study consists of scientific publications presented in domestic and foreign peer-reviewed journals dedicated to the issues of quality of life and psychosocial adaptation in oncological hematological diseases. The analysis included data from statistical reports and materials from clinical guidelines. The methodological basis of the work included theoretical analysis and synthesis of information, systematization of the obtained data, as well as a comparative method. The main conclusions of the conducted research are the identified nonlinear dynamics of quality of life with a significant decrease in all indicators in the early post-transplantation period and subsequent incomplete recovery, with physical functioning improving faster than psychological and social condition. The novelty of this study lies in the detailed analysis of the age-specific characteristics of patients aged 15–25 and the justification of the need to consider the conflict between developmental tasks and the forced halt of life trajectory. A special contribution from the author is the identification of the persistent nature of psychosocial disturbances, which remain despite a good somatic status, determining the need for long-term psychological support during the patient’s return to society. The results obtained indicate that standard medical criteria for transplantation success do not guarantee the full restoration of patients' subjective well-being.
Anton Mihailovich Parfenov (Thu,) studied this question.