A Comprehensive Overview of Floating Drug Delivery System

Floating Drug Delivery Systems (FDDS) are oral dosage forms designed to float on the gastric contents, prolonging their residence time in the stomach and facilitating sustained release of the active pharmaceutical ingredient. Conventional drug delivery systems often suffer from limitations such as frequent dosing and low bioavailability, particularly in relation to rapid gastric emptying. Floating drug delivery systems have garnered significant attention in recent decades as a viable solution to these drawbacks. An optimal floating system is designed to reside in the stomach for a prolonged period, releasing the active pharmaceutical ingredient in a sustained manner. By floating on gastric contents, these systems achieve extended pharmacological effects, ultimately enhancing drug bioavailability. This review aims to provide a comprehensive overview of floating tablets, advantages, disadvantages, classification, preparation methods, evaluation techniques, and applications.