What question did this study set out to answer?

Investigate whether maternal viral infections during pregnancy are associated with congenital heart disease in offspring.

January 16, 1967JAMA

Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease

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Why the study?

Does maternal coxsackievirus infection during pregnancy increase the risk of congenital heart disease in infants?

Population

Pregnant women (mothers of infants with congenital heart disease and matched control women)

Comparison

Maternal coxsackievirus infection during pregnancy vs Matched control women

Design

Case-control

Authors

GBGordon C. BrownUniversity of Oxford

Discussion

Member takes

Implication

Should not yet change prenatal care; hypothesis-generating for causality in congenital heart disease.

Key Points

Investigate whether maternal viral infections during pregnancy are associated with congenital heart disease in offspring.
Conducted serologic testing for viral infections in mothers of infants with congenital heart disease compared to matched control mothers.
Tracked maternal illness symptoms and infection timing across gestation using patient diaries kept during pregnancy.
Mothers of infants with congenital heart disease experienced significantly higher rates of Coxsackievirus infection than matched controls, predominantly involving Coxsackievirus B types 3 and 4.
Most Coxsackievirus infections occurred during the first trimester, with patient illness diaries revealing that half of these maternal infections were completely subclinical.
No significant difference in the incidence of other tested viral infections was observed between the anomaly and control cohorts.

Structured PICO

Does maternal coxsackievirus infection during pregnancy increase the risk of congenital heart disease in infants?

Population

Pregnant women (mothers of infants with congenital heart disease and matched control women)

Intervention

Maternal coxsackievirus infection during pregnancy (exposure)

Comparator

Matched control women (mothers of infants without congenital heart disease)

Outcome

Congenital heart disease in infantshard clinical

Maternal coxsackievirus infection, particularly types B3 and B4 during the first trimester, is associated with an increased risk of congenital heart disease in offspring.

Cite This Study

Gordon C. Brown (1967) studied this question.

synapsesocial.com/papers/69d3d641f48e02b265ed07f6 https://doi.org/10.1001/jama.1967.03120030087016

Topics

Congenital heart disease adults

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Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Serologic Evidence of Coxsackievirus Etiology of Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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