Therapeutic strategies reducing acute neutrophil-driven inflammation post-MI must be carefully balanced to avoid interfering with the healing response and cardiac remodeling.
Neutrophils are crucially involved in cardiac repair after MI by polarizing macrophages towards a reparative phenotype. Therapeutic strategies to reduce acute neutrophil-driven inflammation after MI should be carefully balanced as they might interfere with the healing response and cardiac remodelling.
Horckmans et al. (2016) studied this question.