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This research investigates the role of glycocholic acid in regulating immune responses in colorectal cancer.

April 7, 2026Nature CommunicationsOpen Access

Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer

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Reveals that glycocholic acid increases PD-L1 expression in colorectal cancer, suggesting new treatment strategies.

This research investigates the role of glycocholic acid in regulating immune responses in colorectal cancer.
Analyzed serum bile acids in colorectal cancer patients
Utilized a mouse model of CRC to study tumor immune interactions
Investigated the mechanisms involving FXR, SOX14, and DHHC9
Assessed the effects of silencing SOX14 or DHHC9 and activating FXR alongside anti-PD-1 therapy
Glycocholic acid was elevated in CRC patient serum
GCA enhanced PD-L1 expression, reducing T cell immunity
Inhibition of FXR led to increased SOX14, affecting PD-L1 stability
Combining FXR activation or gene silencing with anti-PD-1 therapy reduced tumor growth

Zhao et al. (2026) studied this question.

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