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April 7, 2026Discover OncologyOpen Access

Isthmic papillary thyroid microcarcinoma: clinicopathological features and prognostic factors following isthmusectomy based on tumor size stratification

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Authors

FZFeng ZhuCLCuiwei LiYSYiBin Shen

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Overview

Retrospective analysis compares recurrence risk based on tumor size in cN0 isthmic papillary thyroid microcarcinoma, suggesting key prognostic factors.

Key Points

  • This study aims to compare clinicopathological features and recurrence risk based on tumor size in solitary isthmic papillary thyroid microcarcinoma.
  • Conducted a retrospective review of 201 cN0 patients with solitary isthmic PTMC treated with isthmusectomy.
  • Excluded patients with preoperative high-risk features.
  • Performed subgroup analyses comparing characteristics of tumors ≤ 5 mm and > 5 mm.
  • Utilized univariate and multivariate Cox models to identify predictors of recurrence-free survival.
  • Significant differences in tumor size and central lymph node metastasis between the two groups.
  • Recurrence observed in 4.5% of patients, significantly associated with tumors > 5 mm and central lymph node metastasis.
  • Metastatic central lymph nodes > 3 identified as a key predictor of recurrence.
  • Kaplan–Meier analysis showed worse recurrence-free survival for tumors > 5 mm.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69d49fa9b33cc4c35a228139https://doi.org/10.1007/s12672-026-04950-0
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