Why the study?
Does aerobic exercise inhibit sympathetic nerve sprouting and restore β-adrenergic receptor balance in rats with myocardial infarction?
Does aerobic exercise inhibit sympathetic nerve sprouting and restore β-adrenergic receptor balance in rats with myocardial infarction?
Aerobic exercise provides cardioprotective autonomic benefits post-myocardial infarction in rats by inhibiting sympathetic nerve sprouting and restoring β-adrenergic receptor balance via NOS activation.
Hypothesis-generating in rat MI models; leaves open human translation and requires prospective trials before any clinical consideration.
Aerobic exercise inhibits cardiac sympathetic nerve sprouting, restores β3-AR/β1-AR balance and increases β3-AR expression through the activation of NOS2 and NOS1 after myocardial infarction.
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Chen et al. (2014) studied this question.
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